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Results 1 - 8 of 8
EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.3.1.294malfunction an inactive enzyme-deficient mutant has less density of mycolic acid, embedded in periplasmic space, with normal thickness in the cell envelope, which results in loss of acid-fastness -, 755625
Display the reaction diagram Show all sequences 2.3.1.294malfunction enzyme gene deletion in Mycobacterium tuberculosis causes loss of acid-fastness and subclinical latent tuberculosis in immunocompetent mice. An additional outcome of enzyme gene deletion is the loss of ketomycolic acid trans-cyclopropanation and a drastic reduction in methoxymycolic acid trans-cyclopropanation. Although deletion of the enzyme also markedly alters the colony morphology and abolishes classic serpentine growth (cording), the most profound effect of enzyme gene deletion is the ability of the mutant strain to persist in infected immunocompetent mice for up to 600 days without causing disease or mortality 755237
Display the reaction diagram Show all sequences 2.3.1.294malfunction enzyme mutants exhibit strikingly altered cell wall permeability, leading to a marked increase in susceptibility to lipophilic antibiotics and the host antimicrobial molecules defensing and lysozyme. The predominant chain lengths are 2-4 carbons shorter for oxygenated mycolates in the absence of the enzyme -, 754769
Display the reaction diagram Show all sequences 2.3.1.294metabolism the enzyme can catalyze both saturated and unsaturated fatty acid biosynthesis 752750
Display the reaction diagram Show all sequences 2.3.1.294metabolism the enzyme is involved in fatty acid and mycolic acid biosynthesis -, 754056
Display the reaction diagram Show all sequences 2.3.1.294metabolism when enzyme KasB is coexpressed with KasA, it appears to be capable of facilitating the production of lipids of the length of full meromycolic acids. KasB therefore may accept primers directly from KasA that average 40 carbons in length. KasA and KasB thus function in tandem to carrier out acyl chain elongation to achieve meromycolic acid synthesis from acyl primers provided by type I fatty acid synthase system -, 755623
Display the reaction diagram Show all sequences 2.3.1.294physiological function enzyme-dependent mycolate elongation is essential for cording and cell wall impermeability. Enzyme-dependent cell wall impermeability is essential for antibiotic resistance. The enzyme is essential for resistance to macrophage antimicrobial activity -, 754769
Display the reaction diagram Show all sequences 2.3.1.294physiological function the enzyme is involved in cording and acid-fast staining and is required for survival and virulence in infected mice -, 754770
Results 1 - 8 of 8