  2.3.1.290 | physiological function |
the polyketidsynthase system consists of 4 subunits. SpnA is an iterative modular type I polyketide synthase. Six PKS modules of the spectinabilin cluster catalyze seven rounds of elongation and reduction. SpnA' is a biomodular protein of the same domain architecture of SpnA (ketosynthase, acyl transferase, dehydratase, ketoreductase and acyl carrier protein), which is responsible for two successive unsaturated chain elongation steps using methylmalonyl-CoA. SpnB contains a sequence of malonyl-CoA specificity in the AT domain, which leads to a full reduction of the beta-keto group after condensation of malonyl-coA.7 SpnC carries two modules of ketosynthase, acyl transferase, and acyl carrier protein domains and a C-terminal thioesterase domain and catalyzes the last two Claisen condensations |
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