EC Number   |
General Information |
Reference |
|---|
    2.3.1.181 | evolution |
LipM and LipL phylogenetic tree analysis, overview |
718134 |
| 2.3.1.181 | malfunction |
biallelic mutations in LIPT2 cause a mitochondrial lipoylation defect associated with severe neonatal encephalopathy |
755761 |
| 2.3.1.181 | malfunction |
DELTAlipL strains are unable to synthesize lipoic acid despite the presence of LipM and the sulfur insertion enzyme, LipA, which should suffice for lipoic acid biosynthesis. Strain NM57 DELTAlipM is auxotrophic for lipoic acid when grown in minimal medium but grew as well as the wild type strain JH642 in the presence of lipoic acid |
718133 |
| 2.3.1.181 | malfunction |
first 31 amino acids of the N-terminus of LIPT2 represent a mitochondrial targeting sequence and inhibition of the transit of LIPT2 to the mitochondrion results in apoptotic cell death associated with activation of the apoptotic volume decrease current in normotonic conditions, as well as over-activation of the swelling-activated chloride current, mitochondrial membrane potential collapse, caspase-3 cleavage and nuclear DNA fragmentation |
758153 |
| 2.3.1.181 | malfunction |
lack of the AtLIP2p2 isoform results in decrease in palmitic acid, 16:0, and polyunsaturated fatty acids at the expenses of oleate and significant increases of the seed oil content |
-, 757578 |
| 2.3.1.181 | malfunction |
the silencing of Lip2p1 results in a significant decrease in 16:0 and 18:3 fatty acids accompanied by an increase in 18:1 and 18:2 content |
-, 757578 |
| 2.3.1.181 | metabolism |
LIPT2 is required in intramitochondrial lipoate synthesis |
755761 |
| 2.3.1.181 | metabolism |
The apicoplast-specific LipB is dispensable for parasite growth due to functional redundancy of the parasites lipoic acid/octanoic acid ligases/transferases. |
706425 |
| 2.3.1.181 | metabolism |
the enzyme initiates lipoyl group assembly |
758242 |
| 2.3.1.181 | metabolism |
the enzyme is involved in the biosynthesis of lipoyl cofactor |
-, 757578 |
