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Results 1 - 7 of 7
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.142malfunction in the absence of Erf4, the rate of hydrolysis of the active site palmitoyl thioester intermediate is increased, resulting in reduced palmitoyl transfer to a Ras2 substrate 720041
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.142more active site of rGlnA1 for TAase activity, overview 720381
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.142more Erf4 and the C-terminal 58 amino acids of Erf2 are required for Erf2 stability. Role of the quality control system in degrading Erf2 molecules that are not in complex with Erf4. The C-terminal 58-amino acid residues of Erf2 are necessary and sufficient for ubiquitin-dependent, ERAD-mediated clearance of DHHC PATs 720041
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.142more the P-domain of recombinant calreticulin, unlike its N- and C-domains, is endowed with CRTAase function 720984
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.142physiological function GlnA1 is a virulence determinant factor. The extracellular secretion of GlnA1 in large amounts is thought to play an important role in the biosynthesis of poly L-glutamate/glutamine cell wall 720381
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.142physiological function histone H4 protein is subject to palmitoylation catalyzed by Lpcat1 in a calcium-regulated manner. Cytosolic Lpcat1 shifts into the nucleus in lung epithelia in response to exogenous Ca2+. Nuclear Lpcat1 colocalizes with and binds to histone H4, where it catalyzes histone H4 palmitoylation. Residue Ser47 within histone H4 serves as a putative acceptor site, indicative of Lpcat1-mediated O-palmitoylation. Lpcat1 knock-down or expression of a histone H4 Ser47A mutant protein in cells decrease cellular mRNA synthesis 719950
Display the word mapDisplay the reaction diagram Show all sequences 2.3.1.142physiological function palmitoylation is a reversible modification involved in protein membrane targeting, receptor trafficking and signaling, vesicular biogenesis and trafficking, protein aggregation, and protein degradation. An example of the dynamic nature of this modification is the palmitoylation-depalmitoylation cycle that regulates the subcellular trafficking of Ras family GTPases. The Ras protein acyltransferase consists of a complex of Erf2-Erf4 in yeast cells. Both subunits Erf2 and Erf4 are required for PAT activity, one role of Erf4 is to regulate Erf2 stability through an ubiquitin-mediated pathway. Erf4 is required for the stable formation of the palmitoyl-Erf2 intermediate, the first step of palmitoyl transfer to protein substrates 720041
Results 1 - 7 of 7