EC Number |
General Information |
Reference |
---|
2.3.1.1 | malfunction |
enzyme deficiency results in elevated levels of plasma ammonia which is neurotoxic |
737116 |
2.3.1.1 | metabolism |
Sulfolobus solfataricus lacks ornithine acetyltransferase and thus forms N-acetylglutamate exclusively via the energetically less favourable reaction catalysed by N-acetylglutamate synthase, investing 1 mol of acetyl CoA per mol of N-acetyl intermediate synthesized |
-, 725629 |
2.3.1.1 | physiological function |
first enzyme of bacterial and plant arginine biosynthesis, activator of urea cycle in animals |
703696, 703712 |
2.3.1.1 | physiological function |
first step in L-arginine biosynthesis in plants and micro organsims, inactive T-state with L-arginine bound and active R-state complexed with CoA and L-glutamate |
704614 |
2.3.1.1 | physiological function |
N-acetylglutamate synthase catalyzes the synthesis of N-acetyl-L-glutamate, an obligate cofactor for carbamyl phosphate synthetase I in the urea cycle. An N-terminal proline-rich motif of the enzyme is likely to function in signal transduction to carbamyl phosphate synthetase I, CPS1 |
737116 |
2.3.1.1 | physiological function |
the enzyme plays a role in citrulline and/or arginine biosynthesis during the first day of development and in ammonia detoxification thereafter |
737139 |