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Results 1 - 10 of 22 > >>
EC Number General Information Commentary Reference
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3malfunction growth deficiency phenotypes (in un-supplemented M9 minimal medium containing thymidine) are direct consequences of the gene deletions -, 757625
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3malfunction inhibition of the enzyme results in depletion of purine nucleotides 736619
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3malfunction insulin stimulation and enzyme ATIC knockdown readily increase the level of AMP-activated protein kinase-Thr172 phosphorylation in insulin receptor complexes. Enzyme ATIC, protein-tyrosine phosphatase-like A domain-containing protein 1, and AMP-activated protein kinase knockdown affects insulin receptor internalization in HEK-293 cells 736802
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3malfunction insulin stimulation and enzyme ATIC knockdown readily increase the level of AMPK-Thr172 phosphorylation in insulin receptor complexes 736802
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3malfunction the ATIC rs2372536 GG enzyme genotype is associated with improved clinical remission in juvenile idiopathic arthritis during methotrexate therapy, only one of the ATIC single nucleotide polymorphisms show any trend toward methotrexate response in an independent cohort of North American juvenile idiopathic arthritis children 737222
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3metabolism aminoimidazolecarboxamide ribotide transformylase is involved in the de novo purine nucleotide biosynthesis 719415
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3metabolism aminoimidazolecarboxamide ribotide transformylase is involved in the de novo purine nucleotide biosynthesis. No enzyme complex that generates 10-formyl-5,6,7,8-tetrahydrofolate and immediately channels or furnishes it to AICAR transformylase is needed because the first oxidation product of 10-formyl-5,6,7,8-tetrahydrofolate is 10-formyl-7,8-dihydrofolate that is utilized by this transformylase 719415
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3metabolism last and rate-limiting enzyme of the de novo purine synthesis pathway 736802
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3metabolism last enzyme of the de novo purine synthesis pathway. The enzyme plays a central role in insulin signaling and the Golgi/endosomes protein network 757662
Show all pathways known for 2.1.2.3Display the word mapDisplay the reaction diagram Show all sequences 2.1.2.3metabolism the 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/inosine monophosphate (IMP) cyclohydrolase (ATIC) catalyzes final two steps of purine nucleotide de novo biosynthetic pathway. The cell proliferation activity of the enzyme is observed where it promotes proliferation and viability of NIH 3T3 and RIN-5F cells, exhibits in vitro wound healing in NIH 3T3 fibroblast cells, and rescues RIN-5F cells from the cytotoxic effects of palmitic acid and high glucose 756701
Results 1 - 10 of 22 > >>