EC Number   |
General Information |
Reference |
|---|
    2.1.1.5 | metabolism |
involved in homocystein metabolism |
704793 |
| 2.1.1.5 | physiological function |
betaine homocysteine methyltransferase is a potential cargo-based end-point marker for macroautophagy |
701995 |
| 2.1.1.5 | physiological function |
high-fat-diet-pretreated mice fed with no-added zinc diet for 4 weeks have the lowest gene and protein expression of betaine homocysteine-S-methyltransferase, cystathionine beta-synthase, and zinc-dependent transcription factor Sp1, compared with control diet or low-fat-diet pretreatment |
756136 |
| 2.1.1.5 | physiological function |
identification of interactions of betaine homocysteine S-methyltransferase in normal liver. S-methylmethionine homocysteine methyltransferase or betaine homocysteine methyltransferase 2, methionine adenosyltransferases alpha1 and alpha2, cAMP-dependent protein kinase catalytic subunit alpha, 4-hydroxyphenylpyruvic acid dioxygenase and aldolase b. Network analysis identified 122 nodes and 165 edges, as well as a limited number of KEGG pathways that comprise the biosynthesis of amino acids, cysteine and methionine metabolism, the spliceosome and metabolic pathways |
758172 |
| 2.1.1.5 | physiological function |
in blastocysts, mean inner cell numbers decrease from18-19 in controls to 11-13 when the folate cycle is inhibited by the antifolate methotrexate and to 12-14 when BHMT expression is knocked down by antisense morpholinos. Inhibiting both pathways more severely affects inner cellmass development (7-8 cells).Total SAM levels in mouse blastocysts decrease significantly only when both pathways are inhibited (from 3.1 to 1.6 pmol/100 blastocysts). DNA methylation is minimally affected by inhibition of either pathway alone but decreases by at least 45-55% when both BHMT and the folate cycle are inhibited simultaneously |
733821 |
| 2.1.1.5 | physiological function |
in hybernating bats, homocysteine level does not elevate in brains, despite declining vitamin B levels. At low levels of vitamin B6 and B12, no change in total expression level of methionine synthase and cystathionine beta-synthase is found, but a 1.85fold increase in the expression of the coenzyme-independent betaine-homocysteine S-methyltransferase |
735112 |
| 2.1.1.5 | physiological function |
in rats fed methionine and choline-deficient diet, betaine supplementation reverses the reduction of methionine and S-adenosylmethionine, and the elevation of homocysteine levels in the liver, due to the induction of betaine-homocysteine methyltransferase and methionine adenosyltransferase MAT |
755939 |
