EC Number   |
General Information |
Reference |
|---|
  2.1.1.371 | physiological function |
ectopic expression of SET1 increases the amount of dimethylated H3K9 and induces chromosome-segregation defects in tobacco BY2 cells. The histone methyltransferase activity, the association with specific chromatin regions and with condensed chromosomes, and the cellular effects largely depend on the C-terminal region including the SET domain of the protein. The N-terminal part of SET1 is capable of targeting the green fluorescent protein to interphase chromatin. SET1 binds LHP1, the Arabidopsis homolog of animal heterochromatin protein 1, and LHP1 colocalizes with heterochromatin containing high amounts of dimethylated H3K9 |
758007 |
| 2.1.1.371 | physiological function |
noncatalytic splice variant NSD3S has with oncogenic activity and appears to bind, stabilize, and activate the transcriptional activity of trancription factor MYC. NSD3S binds to MYC and reduces the association of F-box and WD repeat domain containing FBXW7 with MYC, which results in suppression of FBXW7-mediated proteasomal degradation of MYC and an increase in MYC protein half-life. A 15-amino acid peptide of NSD3S mediates MYC binding |
759635 |
| 2.1.1.371 | physiological function |
Nsd3 dimethylates H3K4 and additionally di-, and tri-methylates histones H3K27. Overexpression of Nsd3 represses transcription of the SV40 promoter |
755933 |
| 2.1.1.371 | physiological function |
siRNA directed depletion of NSD3L identified NSD3L regulated genes linked to cellular signaling pathways such as cell growth, cell cycle, cell motility, transcription, and apoptosis. Up-regulated genes are the cell cycle regulators E2F2 and Arl2. NSD3L depletion results in an increase in the number of cells in the S and G2/M cell cycle phases. NSD3L depletion increases the invasiveness of MDA-MB-231 breast cancer cells |
758721 |
