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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.1.1.342physiological function the gene, and the corresponding protein, is part of a heme uptake and utilization operon that is common to several enteric pathogens. The physiological role of the gene cluster (ChuW, ChuX, and ChuY) is the liberation of iron during colonization and infection of the intestine. ChuW catalyzes the anaerobic degradation of heme to release iron and produce a reactive tetrapyrrole termed anaerobilin 756064
Display the reaction diagram Show all sequences 2.1.1.342physiological function the oxygen-independent heme degradation pathway of Escherichia coli O157:H7 consists of ChuW, a radical SAM methyltransferase, which methylates heme to form the linear tetrapyrrole anaerobilin and liberate iron. ChuY uses anaerobilin as a substrate, reducing it to the tetrapyrrole termed anaerorubin 740091
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