EC Number   |
General Information |
Reference |
|---|
   2.1.1.320 | drug target |
drug target due to its critical function in cancer |
756193 |
| 2.1.1.320 | drug target |
targeting PRMT5 offers a great opportunity to combat cancer in an efficient and selective way |
757401 |
| 2.1.1.320 | drug target |
the enzyme is a promising therapeutic target for human cancer |
756191 |
| 2.1.1.320 | malfunction |
prmt5 loss in zebrafish leads to the expression of an infertile male phenotype due to a reduction in germ cell number, an increase in germ cell apoptosis and the failure of gonads to differentiate into normal testes or ovaries. Arginine methylation of the germ cell-specific proteins Zili and Vasa, as well as histones H3 (H3R8me2s) and H4 (H4R3me2s), is reduced in the gonads of prmt5-null zebrafish |
756552 |
| 2.1.1.320 | physiological function |
arginine methyltransferases type II PRMT5 and type I PRMT4 mutants show similar alterations in flowering time, photomorphogenic responses and salt stress tolerance, while only prmt5 mutants exhibited alterations in circadian rhythms. PRMT5 and PRMT4s coregulate the expression and splicing of key regulatory genes associated with transcription, RNA processing, responses to light, flowering, and abiotic stress tolerance |
733576 |
| 2.1.1.320 | physiological function |
at 10 hours post-fertilization, Prmt7 morphants display an epibolic delay defects phenotype compared with control embryos that have completed epiboly and entirely enclosed the yolk sphere. Both shape and orientation of enveloping layer cells in Prmt7 morphants are altered. In control embryos, enveloping layer cells are elongated and regularly aligned. Enveloping layer cells in Prmt7 morphants are mostly round, small, and irregularly aligned more disorganized and fail to align their cell bodies along the direction of epibolic movement |
734504 |
| 2.1.1.320 | physiological function |
both PRMT5 alone and PRMT5 in complex with MEP50 are able to generate di-methylated H4 peptide product. The PRMT5:MEP50 complex consistently has a higher level of methyltransferase activity compared with PRMT5 |
735162 |
| 2.1.1.320 | physiological function |
Caenorhabditis elegans lacking PRMT-5 are hypersensitive to dilute octanol. PRMT-5 contributes to the regulation of locomotion by both exogenous and endogenous dopamine |
735271 |
| 2.1.1.320 | physiological function |
deletion of Prmt5 results in germ cell depletion in adult mice. Germ cell loss is first observed between embryonic days 12.5 and 13.5, and very few of these cells remain at birth. Oct4, Sox2, and Nanog are abundantly expressed in Prmt5-deficient germ cells, whereas their expression is dramatically decreased in control germ cells. The expression of meiosis-associated genes is virtually absent in Prmt5-deficient female germ cells at embryonic day 13.5 , whereas the expression of other germ cell-specific genes is not changed. Methylation of histine H4R3 is completely absent after Prmt5 inactivation, whereas the level of histone H3R2 is not changed |
733457 |
| 2.1.1.320 | physiological function |
epigenetic regulation by the type II protein arginine methyltransferase, PRMT5, plays an essential role in the control of cancer cell proliferation and tumorigenesis. PRMT5 governs expression of prosurvival genes by promoting WNT/beta-CATENIN and AKT/GSK3x02 proliferative signaling |
757233 |
