EC Number   |
General Information |
Reference |
|---|
   2.1.1.319 | drug target |
given the dual functions of PRMT1 (promotion of migration and invasion and inhibition of proliferation in gastric cancer cells), it is a potential drug target of gastric cancer with extreme caution |
756671 |
| 2.1.1.319 | drug target |
investigation of the role of the enzyme (PRMT2) in breast cancer progression and for developing a new endocrine therapeutic strategy for breast cancer patients with tamoxifen resistance |
757882 |
| 2.1.1.319 | drug target |
PRMT6 is overexpressed in several cancer types and is therefore considered as a potential anti-cancer drug target |
757509 |
| 2.1.1.319 | drug target |
protein arginine N-methyltransferase 1 expression is significantly upregulated in hepatocellular carcinoma cell lines and clinical tissues. Downregulation of protein arginine N-methyltransferase 1 in hepatocellular carcinoma cells by small interfering RNA could inhibit cell proliferation, migration, and invasion in vitro. The enzyme may contribute to hepatocellular carcinoma progression and serves as a promising target for the treatment of hepatocellular carcinoma patients |
758525 |
| 2.1.1.319 | drug target |
the enzme is associated with several human cancers including breast, colon, prostate and lung cancers and thus, is a potential oncological target |
757564 |
| 2.1.1.319 | drug target |
the enzyme (PRMT1) is a promising target for the treatment of cancer |
756181 |
| 2.1.1.319 | malfunction |
disruption of CARM1 enhances the nuclear retention of mRNAs containing inverted repeated Alu elements (IRAlus) |
756878 |
| 2.1.1.319 | malfunction |
knockdown of PRMT1 reverses epithelial-mesenchymal transition in HCC cell lines and inhibits the proliferation of HepG2 and Hep3B cells |
758525 |
| 2.1.1.319 | malfunction |
loss of Carm1 leads to a low sperm count and deformed sperm heads that can be attributed to defective elongation of round spermatids. RNA-seq analysis of Carm1-null spermatids reveals that the deregulated genes fell into similar categories as those impacted by p300-loss, thus providing a link between Carm1 and p300 (a major Carm1 substrate). CREMtau, a key testis-specific transcription factor, associates with p300 through its activator, ACT. This interaction is negatively regulates by the methylation of p300 by Carm1. Thus, high nuclear Carm1 levels negatively impact the p300/ACT/CREMtau axis during late stages of spermiogenesis |
757852 |
| 2.1.1.319 | malfunction |
Prmt1 ablation in adipocytes impairs thermogenic activation induced by cold exposure or beta3-adrenergic stimulation. Loss of enzyme (PRMT1) in mature adipocytes does not affect adipose tissue function at basal level. Loss of PRMT1 or overexpression of PRMT1 does not affect adipogenesis in fat cells |
756600 |
