EC Number   |
General Information |
Reference |
|---|
   2.1.1.248 | metabolism |
archaeal methane formation from methylamines is initiated by distinct methyltransferases with specificity for monomethylamine, dimethylamine, or trimethylamine. Each methylamine methyltransferase methylates a cognate corrinoid protein, which is subsequently demethylated by a second methyltransferase to form methyl-coenzyme M, the direct methane precursor |
717781 |
| 2.1.1.248 | metabolism |
biochemistry of methane formation by Methanosarcina species from monomethylamine, dimethylamine, and trimethylamine: methanogenesis from these substrates is initiated by three methyltransferases that specifically methylate their cognate corrinoid proteins with one of these methylamines, cf. EC 2.1.1.250 and EC 2.1.1.249, overview |
717525 |
| 2.1.1.248 | metabolism |
when growing on trimethylamine, nitrogen fixation does not occur in the cells, indicating that ammonium released during trimethylamine degradation is sufficient to serve as a nitrogen source and represses nif gene induction, transcriptional regulation of soluble methyltransferases, which catalyze the initial step of methylamine consumption by methanogenesis, in response to different carbon and nitrogen sources, overview. Regulation of soluble methyltransferases in response to different nitrogen and carbon sources, overview |
-, 717723 |
| 2.1.1.248 | more |
single in-frame amber UAG codons are found in the genes encoding MtmB, MtbB, or MttB, the methyltransferases initiating methane formation from monomethylamine, dimethylamine, or trimethylamine, respectively, in certain Archaea. The amber codon codes for pyrrolysine, the 22nd genetically encoded amino acid found in nature |
-, 717771 |
| 2.1.1.248 | more |
the enzyme contains pyrrolysine at the UAG posotion, crystal structure of MtmB reveals lysine, but with epsilonN in amide linkage with (4R,5R)-4 substituted-pyrroline-5-carboxylate |
717525 |
| 2.1.1.248 | physiological function |
the enzyme is involved in the corrinoid-dependent demethylation of methylamines, which are used for coenzyme M methylation, homology modeling of MtmC, the methylamine-specific corrinoid protein. Pyrrolysine in MtmB mediates methylation of MtmC |
717525 |
| 2.1.1.248 | physiological function |
the MMAMT polypeptide is rate-limiting for methyl transfer until at a 2fold molar excess over monomethylamine corrinoid protein, MMCP. MMAMT and MMCP form a complex. MMCP is the major corrinoid protein for methanogenesis from monomethylamine |
717757 |
