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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 2.1.1.190evolution YefA is a COG2265 member. During evolution, COG2265 enzymes have undergone a series of changes in target specificity and YefA is closer to an archetypical m5U methyltransferase. A functional shift has occurred during the evolution of the Bacillus subtilis YefA and YfjO methyltransferases.To reflect its dual specificity, YefA is renamed RlmCD 720592
Display the reaction diagram Show all sequences 2.1.1.190malfunction strains lacking the RumA methylase are gradually out-competed by wild type strains in growth competition experiments, suggesting that the m5U methylation improves ribosome performance. Base substitutions at U1939 in 23S rRNA have little effect on growth or the fidelity of translation, but alter the sensitivity of the ribosomes to the antibiotics fusidic acid and capreomycin 702095
Display the reaction diagram Show all sequences 2.1.1.190physiological function RlmD is the archetypical enzyme that is specific for m5U1939 in 23S rRNA 721031
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