EC Number   |
General Information |
Reference |
|---|
   2.1.1.178 | malfunction |
DELTArsmF null mutant bacteria have a decreased susceptibility to aminoglycosides, including 4,6- and 4,5-deoxystreptamine aminoglycosides |
-, 718596 |
| 2.1.1.178 | malfunction |
inactivation of the yebU gene leads to loss of methylation at C1407 in 16S rRNA. yebU knockout strains display slower growth and reduced fitness in competition with wild-type cells (at 37°C and 42°C) |
705111 |
| 2.1.1.178 | malfunction |
lack of enzyme does not entail a fitness cost to the host |
-, 735241 |
| 2.1.1.178 | metabolism |
two methyltransferases, RsmB and RsmF, are responsible for all four 5-methylcytidine modifications in 16S rRNA of Thermus thermophilus, overview. RsmB produces m5C967, while RsmF methylates C1400, C1404, and C1407 in a 30S subunit substrate, but only C1400 and C1404 when naked 16S rRNA is the substrate. C1400 and C1404 are sufficiently buried in the mature ribosome structure so require extensive unfolding of the rRNA to be accessible to RsmF |
-, 721025 |
| 2.1.1.178 | physiological function |
the housekeeping methylation at C1407 is involved in intrinsic aminoglycoside susceptibility in Escherichia coli |
-, 718596 |
