EC Number |
General Information |
Reference |
---|
2.1.1.176 | evolution |
Fmu/RsmB/RrmB homologues exist not only in bacteria but also in archaea and eukarya and constitute a large orthologous group in the RNA:m5C methyltransferase family. The sequence of the N-terminal domain is negligibly conserved between the bacterial and archaeal subfamilies |
718474 |
2.1.1.176 | malfunction |
deletion of rsmB in a C-terminal S9 tail deletion strain of Escherichia coli causes significantly increased -1 frameshifting at 37°C |
-, 734085 |
2.1.1.176 | malfunction |
enzyme deficiency does not impact initiation from most codons |
734794 |
2.1.1.176 | metabolism |
two methyltransferases, RsmB and RsmF, are responsible for all four 5-methylcytidine modifications in 16S rRNA of Thermus thermophilus, overview. RsmB produces m5C967, while RsmF methylates C1400, C1404, and C1407 in a 30S subunit substrate, but only C1400 and C1404 when naked 16S rRNA is the substrate |
-, 721025 |
2.1.1.176 | more |
next to the S-adenosyl-L-methionine-binding site is a positively charged cleft, formed between the N- and C-terminal domains, which is conserved in the archaeal PH0851 homologues and seems to be suitable for binding the RNA substrate |
718474 |