EC Number   |
General Information |
Reference |
|---|
    1.8.4.12 | drug target |
MsrB1-dependent reduction of oxidized methionine in proteins may be a regulatory event underlying immunity and inflammatory disease, and a novel target for clinical applications |
765804 |
| 1.8.4.12 | drug target |
the enzyme (MsrB1) may be a therapeutic target with respect to the treatment of hepatocellular carcinoma |
765497 |
| 1.8.4.12 | evolution |
phylogenetic analysis suggested that OsMSRB5 is a B-type MSR with similar structure to MSRBs of other species, and belongs to 2-Cys MSRB |
764578 |
| 1.8.4.12 | malfunction |
cytosolic MsrB7 and MsrB8 knockdown lines are sensitive to oxidative stress |
726146 |
| 1.8.4.12 | malfunction |
deficiency in MsrB enzyme reduces the level of Enterococcus faecalis virulence in a systemic and urinary tract infection model |
-, 712154 |
| 1.8.4.12 | malfunction |
genetic ablation of MsrB1 doesd not preclude LPS-induced intracellular signaling in macrophages, but results in attenuated induction of antiinflammatory cytokines, such as interleukin (IL)-10 and the IL-1 receptor antagonist |
765804 |
| 1.8.4.12 | malfunction |
knockdown of MsrB3A in mammalian cells leads to a significant decrease in the resistance to thapsigargin-induced endoplasmic reticulum (ER) stress, but had no effects on the resistance to either dithiothreitol- or tunicamycin-induced ER stress |
724189 |
| 1.8.4.12 | malfunction |
loss-of-function studies of MsrB2 using virus-induced gene silencing in pepper plants (cultivar Early Calwonder-30R) result in accelerated cell death from an incompatible bacterial pathogen, Xanthomonas axonopodis pv vesicatoria race 1, and enhanced susceptibility to a compatible bacterial pathogen, virulent Xanthomonas axonopodis pv vesicatoria race 3. Suppression of CaMsrB2 increased the production of reactive oxygen species, which in turn results in the acceleration of cell death via accumulation of reactive oxygen species |
713319 |
| 1.8.4.12 | malfunction |
MsrB1 knockdown effectively inhibits tumor growth. MsrB1 knockdown reduces hepatocellular carcinoma cell migration and invasion in a transwell assay through inhibition of cytoskeletal rearrangement and spread |
765497 |
| 1.8.4.12 | malfunction |
the concomitant absence of both protein isoforms MSRB1 and MSRB2 results in a reduced growth for plants cultivated under high light or low temperature, double mutant lines restored for MSRB2 expression display no phenotype, the absence of plastidial MSRBs is associated with an increased chlorophyll a/b ratio, a reduced content of Lhca1 and Lhcb1 proteins, and an impaired photosynthetic performance |
700762 |
