EC Number   |
General Information |
Reference |
|---|
   1.8.1.B1 | drug target |
promising drug target for the treatment of schistosomiasis |
763800 |
| 1.8.1.B1 | drug target |
the enzyme is a promising drug target, as this enzyme is parasite-specific and absent in their host. A study identifies compounds with extremely potent antischistosome activity. Certain compounds are active against all major schistosomes across different life cycle stages |
763813 |
| 1.8.1.B1 | drug target |
the enzyme maybe a potential target for the development of novel agents against opisthorschiasis |
763856 |
| 1.8.1.B1 | physiological function |
the enzyme is able to protect glutamine synthetase from oxidative inactivation, suggesting that the enzyme is competent to contend with oxidative stress |
725773 |
| 1.8.1.B1 | physiological function |
the enzyme is crucial for Opisthorchis viverrini survival |
763856 |
| 1.8.1.B1 | physiological function |
the enzyme is essential for maintaining the thiol-disulfide redox homeostasis of Schistosoma japonicum |
726293 |
| 1.8.1.B1 | physiological function |
the enzyme of the parasite is essential for the survival of schistosomes in the mammalian host |
763812 |
| 1.8.1.B1 | physiological function |
the enzyme plays a crucial role in maintaining redox homeostasis |
724324 |
| 1.8.1.B1 | physiological function |
the enzyme plays a principal role in redox homeostasis maintenance |
764019 |
| 1.8.1.B1 | physiological function |
the enzyme plays an essential role in maintaining the redox homeostasis and antioxidant defenses in the parasite Fasciola gigantica. Parasitic flukes have a limited set of antioxidant proteins in contrast to their mammalian hosts. In platyhelminthic parasites, the two systems (glutathione/glutaredoxin system and thioredoxin system) are replaced by a single system of a multifunctional flavin containing chimeric selenoenzyme known as thioredoxin glutathione reductase, which donates electrons to both thioredoxin disulfide and glutathione disulfide in these parasites |
764023 |
