EC Number |
General Information |
Reference |
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1.7.1.B3 | evolution |
analysis of evolutionary or molecular mechanism of divergence of the nitroreductase/flavin reductase family, overview. The enzyme is similar to NfsA from Escherichia coli, overview |
-, 742109 |
1.7.1.B3 | evolution |
nitroreductases are a family of flavoproteins that catalyze the NAD(P)H-dependent reduction of nitro groups to hydroxylamino and/or amino groups on various nitro-substituted compounds |
743709 |
1.7.1.B3 | more |
comparisons of the quantitative structure-activity relationships of single-electron reduction of quinones and nitroaromatic compounds by dehydrogenase (electron transferase) flavoenzymes, overview |
741786 |
1.7.1.B3 | more |
the enzyme crystal structure of NfsA, PDB ID 1F5V, is used for molecular ligand docking studies |
743709 |
1.7.1.B3 | physiological function |
enzyme is a flavoprotein with NADPH-dependent quinone reductase and nitroreductase activities |
-, 765499 |
1.7.1.B3 | physiological function |
NfsA has potential applications in the biodegradation of nitroaromatic environment pollutants, e.g. explosives, and is also of interest for the anticancer strategy gene-directed enzyme prodrug therapy |
741786 |
1.7.1.B3 | physiological function |
residue Phe42 is critical for the catalytic activity of Escherichia coli major nitroreductase NfsA, Phe42 is important for maintaining NfsA activity and structure |
742167 |