EC Number   |
General Information |
Reference |
|---|
   1.5.99.15 | evolution |
sequence comparisons suggested that the catalytic mechanism is conserved among the bacterial homologues of DmrB and partially conserved in archaeal homologues, where an alternate electron donor is likely used |
742870 |
| 1.5.99.15 | metabolism |
the enzyme catalyzes the final step of methanopterin biosynthesis |
742870 |
| 1.5.99.15 | metabolism |
the microbial production of methane by methanogenic archaea is dependent on the synthesis of the pterin-containing cofactor tetrahydromethanopterin (H4MPT). The enzyme catalyzing the last step of H4MPT biosynthesis is dihydromethanopterin reductase |
-, 742781 |
| 1.5.99.15 | physiological function |
dihydromethanopterin reductase (Dmr) is a redox enzyme that plays a key role in generating tetrahydromethanopterin (H4MPT) for use in one-carbon metabolism. DmrB is a bacterial enzyme that reduces dihydromethanopterin (H2MPT) to H4MPT using flavins as the source of reducing equivalents |
742870 |
| 1.5.99.15 | physiological function |
MJ0208 functions as an archaeal dihydromethanopterin reductase (DmrX) and ferredoxin may serve as an electron donor |
-, 742781 |
| 1.5.99.15 | physiological function |
MM1854 functions as an archaeal dihydromethanopterin reductase (DmrX) and ferredoxin may serve as an electron donor |
-, 742781 |
| 1.5.99.15 | physiological function |
the enzyme catalyzes the last step of tetrahydromethanopterin biosynthesis |
-, 727782 |
