EC Number   |
General Information |
Reference |
|---|
    1.5.3.1 | metabolism |
hydride-transfer is the most energetically favorable mechanism. Hydrogen is not transferred in the hydride state (H-) but in a hydrogen atom state. A single electron is simultaneously transferred from sarcosine to flavin through their overlapping orbitals, the reaction mechanism can be labeled the hydrogen-atom coupled electron-transfer (HACET) mechanism. Sarcosine is moved close to the flavin ring because of a small charge transfer and the positively charged residues (Arg49, Arg52, and Lys348) near the active site play a prominent role in stabilizing the sarcosine-flavin complex |
765533 |
| 1.5.3.1 | more |
the recombinant alpha subunit forms a dimeric structure and behaves as an NADH dehydrogenase, while the beta subunit is a tetramer that has sarcosine oxidase and L-proline dehydrogenase activity.. The SOX complex assembles into the hetero-octameric (alphabeta)4 form and shows NADH dehydrogenase activity, structure of isolated subunit tetramers, overview |
724937 |
| 1.5.3.1 | physiological function |
sarcosine oxidase catalyzes the oxidation of the methyl group in sarcosine and transfer of the oxidized methyl group into the one-carbon metabolic pool, yielding equimolar glycine, hydrogen peroxide, and formaldehyde or 5,10-methylenetetrahydrofolate |
724937 |
