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1.3.1.34
malfunction
the gene disruption of fadH, which 2,4-dienoyl-CoA reductase, impairs production of eicosapentaenoic acid under docosahexaenoic acid-supplemented conditions, and the estimated conversion rate decreases by 86% compared to that of the parent strain
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763076
1.3.1.34
physiological function
DECR is the major reductase involved in polyunsaturated fatty acid beta-oxidation. DECR is related to bacterial reductases. A DECR null mutant is unable to catabolize unsaturated fatty acids and accumulates the intermediate 2,4-decadienoyl-CoA. The mutant is unable to survive in macrophages and is avirulent in BALB/c mice
759709
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