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Results 1 - 7 of 7
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.94evolution the enzyme is a member of the NAD+-dependent class 3 ALDH family of the aldehyde dehydrogenase superfamily -, 742654
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.94malfunction reduction of AaALDH3 activity results in accumulation of farnesal and conversion back to farnesol that leaks outside the corpora allata -, 742654
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.94metabolism in the juvenile hormone JH III biosynthesis in insects, the alcohol farnesol, generated by the removal of diphosphate from farnesyl diphosphate, undergoes oxidation to the aldehyde (farnesal) and then to the acid (farnesoic acid). These steps are catalyzed by one or two NAD+-dependent dehydrogenase(s), JH III biosynthesis pathway, overview 718228
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.94metabolism the enzyme is a biosynthetic enzyme of the juvenile hormone JH pathway -, 742654
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.94physiological function results suggest that in the female Dengue mosquito Aedes aegypti, AaALDH3 enzyme plays a critical role in the regulation of juvenile hormone biosynthesis after blood feeding -, 725133
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.94physiological function the enzyme is a fatty aldehyde dehydrogenase (AaALDH3), NAD+-dependent class 3 ALDH, that oxidizes farnesal into farnesoic acid in the corpora allata of mosquitoes. In corporae allatae of blood-fed females, the low catalytic activity of AaALDH3 limits the flux of precursors and causes a remarkable increase in the pool of farnesal with a decrease in farnesoic acid and juvenile hormone synthesis. The accumulation of the potentially toxic farnesal stimulates the activity of a reductase that converts farnesal back into farnesol, resulting in farnesol leaking out of the corpora allata. Enzyme AaALDH3 plays a key role in the regulation of juvenile hormone synthesis in blood-fed females and mosquitoes seem to have developed a trade-off system to balance the key role of farnesal as a juvenile hormone precursor with its potential toxicity -, 742654
Display the word mapDisplay the reaction diagram Show all sequences 1.2.1.94physiological function the enzyme plays a key role in the regulation of juvenile hormone synthesis in blood-fed mosquito females -, 725133
Results 1 - 7 of 7