EC Number |
General Information |
Reference |
---|
1.2.1.36 | evolution |
aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of the aldehyde dehydrogenase superfamily that oxidizes aldehydes to their corresponding acids, reactions that are coupled to the reduction of NAD+ to NADH |
763529 |
1.2.1.36 | evolution |
the enzyme is a member of the ALDH1 protein family |
743375 |
1.2.1.36 | malfunction |
ablation of retinoic acid signaling in host dencritic cells by deletion of isoform RALDH2 protects mice from acute graft-versus-host disease. Isoform RALDH1 deletion fails to reduce acute graft-versus-host disease |
763337 |
1.2.1.36 | malfunction |
acute inflammation rapidly downregulates ALDH1A1 expression in whole liver while increasing its expression in periportal macrophages |
743375 |
1.2.1.36 | malfunction |
H-1299 cells expressing C302A, E107G, and I304K mutant forms of ALDH1A1 lacked aldehyde-dehydrogenase activity |
763529 |
1.2.1.36 | metabolism |
ALDH1A1 and ALDH3A1 have the same GSH/DHLA-dependent NAD+-reduction activity |
763529 |
1.2.1.36 | metabolism |
both isoforms Raldh1 and -2 contribute to atRA biosynthesis in hippocampus astrocytes |
725461 |
1.2.1.36 | metabolism |
retinaldehyde dehydrogenase 1 induction impairs glucose metabolism partly via modulating phosphoenolpyruvate carboxykinase 1 and glucokinase expressions |
762688 |
1.2.1.36 | metabolism |
the enzyme plays a role in the physiological metabolism of apocarotenoids |
763752 |
1.2.1.36 | more |
enzyme structure comparisons, overview |
763136 |