EC Number   |
General Information |
Reference |
|---|
    1.2.1.19 | evolution |
the enzyme is a member of the aldehyde dehydrogenase 10 family |
741583, 742430, 742521, 742854, 743820 |
| 1.2.1.19 | malfunction |
a mutant strain with disrupted gene gabdh shows an increase in gamma-aminobutyric acid (GABA), glutamate, succinate, and spermidine levels demonstrating a link between spermidine degradation and GABA synthesis in cyanobacteria. A DELTAgad:DELTAkgd strain shows upregulated expression of gene gadbh. Transcription levels of genes related to GABA metabolism in WT and mutants, overview |
763594 |
| 1.2.1.19 | malfunction |
root growth of single loss-of-function mutants is more sensitive to salinity than wild-type plants, and this is accompanied by reduced GABA accumulation |
743820 |
| 1.2.1.19 | metabolism |
AMADH participates in carnitine biosynthesis in plants |
712753 |
| 1.2.1.19 | metabolism |
as alternative to GABA production by glutamate decarboxylation, another route for the production of GABA via putrescine is established in Corynebacterium glutamicum |
741587 |
| 1.2.1.19 | metabolism |
enzyme LrAMADH2 is not involved in glycine betaine biosynthesis |
763552 |
| 1.2.1.19 | metabolism |
in higher plants, glycine betaine (GB) is synthesized by two-step oxidation of choline. The first step is catalyzed by ferredoxin-dependent choline monooxygenase (CMO, EC 1.14.15.7) to produce betaine aldehyde (BAL). BAL is converted to GB by aminoaldehyde dehydrogenase (AMADH, EC 1.2.1.19) containing the activities of betaine aldehyde dehydrogenase (BADH) |
763552 |
| 1.2.1.19 | metabolism |
mannose treatment improves glutamate (Glu) content and the activity of diamine oxidase (DAO), and reduces gamma-aminobutyric acid transaminase (GABA-T) activity, which enriches GABA biosynthesis. Mannose treatment enhances the activities of diamine oxidase (DAO), polyamine oxidase (PAO), and 4-aminobutyraldehyde dehydrogenase (ABALDH), and increases the conversion rate of free polyamine. Mannose treatment may boost the accumulation of GABA in sprouting broccoli, via enhancing GAD activity and providing more glutamate. GABA is degraded by GABA-T, which uses pyruvate or glyoxalate as amino acceptor to convert GABA into succinate semialdehyde (SSA). SSA dehydrogenase catalyzes the irreversible NADP+-dependent oxidation of SSA to succinate. GABA-T activity is significantly reduced in broccoli sprouts under mannose treatment in late growth stage. Polyamines are mainly about free Put, free Spd and free Spm. Arginine is converted to fPut via alternative arginase and ornithine decarboxylase. fPut in turn is converted to fSpd and fSpm via spermidine synthase and spermine synthase, respectively. PAO is responsible for catalyzing the oxidation or back-conversion of fSpm and fSpd, resulting in the formation of 1,3-diaminopropane, and their degradation to 4-aminobutyraldehyde. DAO catalyze the degradation of fPut to 4-aminobutyraldehyde, which in turn are converted to GABA by ABALDH |
763695 |
| 1.2.1.19 | more |
AMADH2 lacks Ile445, that is contained in all enzymes with BADH activity (EC 1.2.1.8) |
763552 |
| 1.2.1.19 | more |
for Ile445 containing AMADHs, the existence of Asn290 rather than Thr290 leads to detectable BADH activity |
763552 |
