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EC Number General Information Commentary Reference
Display the reaction diagram Show all sequences 1.19.1.1physiological function Escherichia coli cells deficient in the soxRS-induced ferredoxin (flavodoxin)-NADP(H) reductase FPR, display abnormal sensitivity to methyl viologen. Neither bacteriostatic effects nor inactivation of oxidant-sensitive hydrolyases can be detected in mutant cells exposed to methyl viologen. FPR inactivation does not affect the methyl viologen-driven soxRS response, FPR overexpression leads to enhanced stimulation of the regulon, with concomitant oxidation of the NADPH pool. Accumulation of a site-directed FPR mutant that uses NAD(H) instead of NADP(H) has no effect on soxRS induction and fails to protect FPR deficient cells from methyl viologen toxicity 738513
Display the reaction diagram Show all sequences 1.19.1.1physiological function flavodoxin, flavodoxin reductase and NADPH function during the activation of the anaerobic ribonucleotide reductase 737584
Display the reaction diagram Show all sequences 1.19.1.1physiological function insertion mutants lacking a functional enzyme do not require methionine and grow well anaerobically, but they show increased sensitivity to paraquat 738503
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