EC Number   |
General Information |
Reference |
|---|
   1.16.1.8 | malfunction |
analysis of correlations of single nucleotide polymorphisms and various malformation anomalies, overview |
745764 |
| 1.16.1.8 | malfunction |
the c.56+781 A>C (rs326119) variant of intron-1 of MTRR significantly increases the risk of congenital heart disease in the Han Chinese population and is highly related to septation defects. The c.56+781 C allele profoundly decreases MTRR transcription. Phenotype, overview |
727334 |
| 1.16.1.8 | metabolism |
the enzyme enzyme plays a key role in homocysteine metabolism |
745034 |
| 1.16.1.8 | metabolism |
the MTRR gene is involved in tumorigenesis by regulating DNA methylation through activation of methionine synthase |
716185 |
| 1.16.1.8 | more |
effects of the MTRR genotype on human status with respect to vitmain B6, plasma folate, homocysteine, and plasma cobalamine levels, modeling, detailed overview |
745034 |
| 1.16.1.8 | more |
genotyping for the A66G polymorphism and analysis of the association with cancer risk reveals that the G allele and GG variant genotypes are associated with a significantly increased cancer risk |
716185 |
| 1.16.1.8 | physiological function |
methionine synthase reductase is essential for the adequate remethylation of homocysteine, which is the dominant pathway for homocysteine removal during early embryonic development |
727334 |
| 1.16.1.8 | physiological function |
methionine synthase reductase, a diflavin oxidoreductase, plays a vital role in methionine and folate metabolism by sustaining methionine synthase activity |
726959 |
| 1.16.1.8 | physiological function |
roles of methionine synthase, MS, and methylenetetrahydrofolate reductase, MTHFR, and methionine synthase reductase, MTRR, in the folate cycle and homocysteine remethylation, overview |
745034 |
