EC Number   |
General Information |
Reference |
|---|
   1.14.17.4 | evolution |
the conserved domains of ACO enzyme from the ACO family of different species are identical by confirming Fe(II)-binding cofactors (His-Xaa-Asp-Xaa-His) and cosubstrate-binding motifs (Arg-Xaa-Ser) |
745036 |
| 1.14.17.4 | malfunction |
enzyme knockout by RNA interference of 1-aminocyclopropane-1-carboxylic acid oxidase (ACO1 and ACO2) genes expression prolongs the shelf life of papaya fruits, overview |
745818 |
| 1.14.17.4 | metabolism |
glutathione (GSH) plays a fundamental role in plant defense-signaling network. GSH can bind residue CYS63 of AtACO1 protein. Transgenic Arabidopsis thaliana plants with enhanced GSH content exhibit remarkable upregulation of ACS2, ACS6, and ACO1 at transcript as well as protein levels, while they are downregulated in the GSH depleted phytoalexin deficient2-1 (pad2-1) mutant. GSH induced ACS2 and ACS6 transcription in a WRKY33-dependent manner, while ACO1 transcription remained unaffected although the mRNA stability for ACO1 is increased by GSH, the ACO1 protein is a subject for S-glutathionylation, while S-glutathionylation of ACS2 and ACS6 proteins is not detected. Transcriptional regulation of gene ACO1, overview. ACO1 expressin is not significantly altered in a wrky33 mutant. GSH-mediated ACO1 regulation is not due to ascorbate limitation. GSH plays a role in maintaining the mRNA stability for ACO1 |
-, 746110 |
| 1.14.17.4 | metabolism |
the enzyme catalyzes the final step in ethylene biosynthesis. The enzyme is involved in the ethylene signal transduction pathway not directly linked to the enzyme reaction |
726692 |
| 1.14.17.4 | metabolism |
the enzyme catalyzes the terminal step in ethylene biosynthesis |
745036, 745625 |
| 1.14.17.4 | metabolism |
the enzyme catalyzes the terminal step in ethylene biosynthesis converting ACC to ethylene, cyanide, CO2, dehydroascorbate and water with inputs of Fe(II), ascorbate, bicarbonate (as activators) and oxygen |
744060 |
| 1.14.17.4 | metabolism |
two tomato ACO genes, LeACO1, and LeACO4 encode the last enzyme in ethylene biosynthesis, 1-aminocyclopropane-1-carboxylate oxidase (ACO) catalyzes the terminal step in ethylene biosynthesis |
745005 |
| 1.14.17.4 | more |
homology modeling and docking analysis reveals that ACO1 is S-glutathionylated on residue CYS63 |
-, 746110 |
| 1.14.17.4 | more |
the binding sites for ACC, bicarbonate and ascorbic acid for Malus domestica ACCO1 include Arg175, Arg244, Ser246, Lys158, Lys292, Arg299 and Phe300. Glu297, Phe300 and Glu301 in alpha-helix 11 are also important for the ACCO reaction. The ACC substrate has been shown to bind to ACCO/Fe(II) in a bidentate manner. ACC oxidase contains several amino acid sequence motifs for putative protein-protein interactions, phosphokinases and cysteine protease. Residue Thr157 is essential for ACCO activity in a protein structural role. Protein-protein interactions and phosphorylation studies with ACCO, overview |
744060 |
| 1.14.17.4 | physiological function |
enzyme ACCO is involved in ethylene biosynthesis. ACCO may be also involved in the ethylene signal transduction pathway not directly linked to the ACCO reaction and may playa role in signal transduction after post-translational processing by functioning as protease and as regulator of 1-aminocyclopropane-1-carboxylic acid synthase (Acs2) gene expression, overview. ACC oxidase is subject to autophosphorylaton in vitro and promotes phosphorylation of some apple fruit proteins in a ripening-dependent manner |
744060 |
