EC Number |
General Information |
Reference |
---|
1.14.15.29 | metabolism |
CYP125 performs an obligate first step in cholesterol degradation. CYP125 is involved in steroid C26-carboxylic acid formation, catalysing the oxidation of C26 either to the corresponding carboxylic acid or to an intermediate state |
718126 |
1.14.15.29 | metabolism |
CYP125A1 is a key enzyme in cholesterol metabolism and plays a crucial role in circumventing the deleterious effect of cholest-4-en-3-one |
-, 718129 |
1.14.15.29 | physiological function |
cyp125 is essential for Rhodococcus jostii strain RHA1 to grow on 3-hydroxysterols such as cholesterol, but not on 3-oxo sterol derivatives |
718126 |
1.14.15.29 | physiological function |
Cyp125 is essential for the growth of Mycobacterium bovis strain bacillus Calmette-Guerin on cholesterol |
-, 717783 |
1.14.15.29 | physiological function |
Cyp125 is not essential for the growth of Mycobacterium tuberculosis on cholesterol |
-, 717783 |
1.14.15.29 | physiological function |
CYP125A1 is required to incorporate the cholesterol side chain carbon atoms into cellular lipids. CYP125A1 is essential for growth of CDC1551 in media containing cholesterol or cholest-4-en-3-one |
-, 718129 |