EC Number |
General Information |
Reference |
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1.14.11.9 | evolution |
no significant genetic differentiation is found between cultivated soybean, Glycine max, and its wild relative, Glycine soja, in the target gene, despite of considering bottleneck and founder effect during domestication. The F3H gene might have experienced gene introgressions or diversifying selection events during domestication process, gene F3H2 appears to evolve under positive selection and enjoy a faster evolutionary rate |
726318 |
1.14.11.9 | evolution |
the enzyme belongs to the 2-oxoglutarate-dependant dioxygenases |
726200 |
1.14.11.9 | evolution |
the enzyme belongs to the 2-oxoglutarate-dependent dioxygenase (2-ODD) family |
743971 |
1.14.11.9 | evolution |
the enzyme belongs to the family of 2-oxoglutarate-dependent dioxygenases |
742957 |
1.14.11.9 | evolution |
the enzyme belongs to the Fe(II)- and 2-oxoglutarate-dependent dioxygenase (2-ODD) superfamily, sharing the conserved motif of pfam 03171. F3H has a jelly roll in the enzyme core, a typical structure shared by all 2-oxoglutarate-dependent dioxygenases including F3Hs. Phylogenetic and molecular evolutionary analyses |
745621 |
1.14.11.9 | evolution |
the enzyme belongs to the Fe2+/2oxoglutarate-dependent dioxygenase superfamily |
744604 |
1.14.11.9 | evolution |
the F3H isozymes have a unique motif of pfam03171 that is maintained in the superfamily of 2-oxoglutarate and Fe(II)-dependent oxygenases |
725165 |
1.14.11.9 | malfunction |
silencing of flavanone-3-hydroxylase leads to an accumulation of flavanones in leaves, but in contrast not to the formation of 3-deoxyflavonoids. In prohexadione-Ca treated leaves the 3-deoxyflavonoid luteoforol is formed from accumulating flavanones, acting as an antimicrobial compound against the fire blight pathogen Erwinia amylovora. Inducible resistance to fire blight by prohexadione-Ca is not observed with the antisense flavanone-3-hydroxylase apple plants |
726200 |
1.14.11.9 | metabolism |
(2S)-flavanones are converted to flavonols by the activity of the 2-oxoglutarate-dependent dioxygenases flavanone 3-hydroxylase (F3H) and flavonol synthase (FLS) |
742957 |
1.14.11.9 | metabolism |
flavanone 3-hydroxylase (F3H) of the flavonoid pathway catalyzes the stereospecific hydroxylation of (2S)-naringenin and (2S)-eriodictyol to form (2R,3R)-dihydrokaempferol and (2R,3R)-dihydroquercetin, respectively. These dihydroflavonols serve as intermediates for the biosynthesis of flavan-3-ols. Enzyme F3H plays a pivotal role in regulation of biosynthesis of flavan-3-ols in Camellia sinensis |
-, 746091 |