EC Number   |
General Information |
Reference |
|---|
   1.14.11.65 | evolution |
KDM3A is a histone demethylase in the JmjC domain-containing protein family |
745951 |
| 1.14.11.65 | evolution |
the enzyme belongs to the JHDM2 (JmjC domain-containing histone demethylase 2) family of enzymes which modulates defense against pathogens and flowering time |
746085 |
| 1.14.11.65 | evolution |
the enzyme belongs to the superfamily of flavin adenine dinucleotide (FAD)dependent amine oxidases |
744188 |
| 1.14.11.65 | evolution |
the enzyme PHF8 is a member of the KDM7 family |
746196 |
| 1.14.11.65 | evolution |
the hairless (HR) protein contains a Jumonji C (JmjC) domain that is conserved among a family of proteins with histone demethylase (HDM) activity |
744861 |
| 1.14.11.65 | malfunction |
an enzyme mutation causes a very severe growth phenotype with a much reduced plant size |
745030 |
| 1.14.11.65 | malfunction |
both pharmacological inhibition of LSD1 and small interfering RNA (siRNA) knockdown prevents interleukin 1beta-induced H3K9 demethylation at the mPGES-1 promoter as well as concomitant mPGES-1 protein expression. The level of LSD1 expression is elevated in osteoarthritis cartilage |
744188 |
| 1.14.11.65 | malfunction |
depletion of LSD1 in an immortalized olfactory-placode-derived cell line (OP6) results in multigenic and multiallelic odorant receptor (OR) transcription per cell, while not seemingly disrupting the ability of these cells to activate new OR genes during clonal expansion. LSD1 depletion does not seem to alter OR representation in OP6 cell populations. Apparent systematic accumulation of H3K4me2 (and possibly H3K9me2) in LSD1-depleted cell populations |
745771 |
| 1.14.11.65 | malfunction |
depletion of LSD1 or inhibition of its activity with monoamine oxidase inhibitors (MAOIs) results in the accumulation of repressive chromatin and a block to viral gene expression. HCF-1 depletion resulted in a concomitant decrease in the recruitment of LSD1 |
754857 |
| 1.14.11.65 | malfunction |
Differentiation of neuroblastoma cells results in down-regulation of LSD1. Small interfering RNA-mediated knockdown of LSD1 decreases cellular growth, induces expression of differentiation-associated genes, and increases target gene-specific H3K4 methylation. LSD1 inhibition using monoamine oxidase inhibitors results in an increase of global H3K4 methylation and growth inhibition of neuroblastoma cells in vitro. Small molecule inhibitors of LSD1 inhibit xenograft tumor growth |
753142 |
