EC Number   |
General Information |
Reference |
|---|
   1.14.11.33 | evolution |
ABH2 is a member of the ABH family DNA repair dioxygenases |
724700 |
| 1.14.11.33 | malfunction |
ABH2 knockdown impairs rDNA transcription and leads to increased single-stranded and double-stranded DNA breaks that are more pronounced in the rDNA genes, whereas ABH2 overexpression protects cells from methyl-methanesulfonate-induced DNA damage and inhibition of rDNA transcription |
724700 |
| 1.14.11.33 | malfunction |
an AlkB-deficient strain accumulates N1-methyladenine at a high rate |
-, 724819 |
| 1.14.11.33 | malfunction |
Escherichia coli alkB mutants are defective in processing methylation damage generated in single-stranded DNA |
716323 |
| 1.14.11.33 | more |
ABH2 associates with DNA repair proteins Ku70/Ku80, overview |
724700 |
| 1.14.11.33 | more |
the recombinant AlkB expressed is less active than the natural endogenous form |
-, 724819 |
| 1.14.11.33 | physiological function |
ABH3 restores the biological function of mRNA and tRNA inactivated by chemical methylation. A methylation-induced block in translation of an mRNA can be readily relieved by treatment with ABH3 prior to translation. Chemical methylation of tRNA-Phe inhibits aminoacylation and translation, but the inhibition can be reversed by ABH3 |
716220 |
| 1.14.11.33 | physiological function |
AlkB corrects some of the unwanted methylations of DNA bases by a unique oxidative demethylation in which the methyl carbon is liberated as formaldehyde. The enzyme also repairs exocyclic DNA lesions |
713602 |
| 1.14.11.33 | physiological function |
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. A methylation-induced block in translation of an mRNA can be readily relieved by treatment with AlkB prior to translation. Chemical methylation of tRNA-Phe inhibits aminoacylation and translation, but the inhibition can be reversed by AlkB |
716220 |
| 1.14.11.33 | physiological function |
AlkB-mediated oxidative demethylation reverses DNA damage |
-, 716324 |
