EC Number   |
General Information |
Reference |
|---|
    1.14.11.1 | drug target |
inhibitors of gamma-butyrobetaine hydroxylase 1 (BBOX1) could be a potential therapeutic option for Triple-negative breast cancer |
765384 |
| 1.14.11.1 | evolution |
comparison of properties, substrate specificities, and structures of the human enzyme (PDB ID 3O2G) and the enzyme from Pseudomonas sp. AK1, detailed overview |
-, 745953 |
| 1.14.11.1 | evolution |
the enzyme belongs to the 2-oxoglutarate/Fe(II) dependent oxygenase family |
-, 744503, 744717, 745684 |
| 1.14.11.1 | evolution |
the enzyme belongs to the superfamily of Fe(II) and 2OG dependent dioxygenases |
744690 |
| 1.14.11.1 | evolution |
the GBBH residues involved in zinc binding are evolutionary conserved in all sequenced eukaryotes more complex than Caenorhabditis elegans |
711108 |
| 1.14.11.1 | metabolism |
gamma-butyrobetaine hydroxylase (BBOX) catalyses the final step in the biosynthesis of carnitine i.e. the stereoselective hydroxylation of gamma-butyrobetaine (GBB) |
-, 745953 |
| 1.14.11.1 | metabolism |
gamma-butyrobetaine hydroxylase (BBOX) catalyses the final step of carnitine biosynthesis |
744690 |
| 1.14.11.1 | metabolism |
last limiting enzyme of the L-carnitine biosynthesis pathway and plays an important role in catalyzing the hydroxylation of gamma-butyrobetaine to L-carnitine |
763867 |
| 1.14.11.1 | metabolism |
the enzyme catalyses the second, essential step of carnitine biosynthesis |
744503 |
| 1.14.11.1 | metabolism |
the enzyme catalyzes the final step in the biosynthesis of L-carnitine in humans |
764457 |
