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1.11.1.20
malfunction
the elevation of intraocular pressure caused by deletion of the enzyme gene likely results from a diversion of the endoperoxide precursor pathway to provide increased levels of those prostanoids known to raise intraocular pressure, namely prostaglandin D2 and thromboxane A2
765698
1.11.1.20
physiological function
prostaglandin ethanolamide, i.e. prostamide, F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide (anandamide) that induces pharmacological actions in ocular tissues. Prostamide/PGF synthase catalyzes the reductions of prostamide H2 to prostamide F2alpha and PGH2 to PGF2alpha, chiefly in the central nervous system
707934
1.11.1.20
physiological function
the enzyme serves an important regulatory role in the eye by providing prostaglandin F2alpha and prostamide F2alpha to constrain the influence of those prostanoids that raise intraocular pressure
765698
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