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EC Number General Information Commentary Reference
Show all pathways known for 1.11.1.20Display the reaction diagram Show all sequences 1.11.1.20malfunction the elevation of intraocular pressure caused by deletion of the enzyme gene likely results from a diversion of the endoperoxide precursor pathway to provide increased levels of those prostanoids known to raise intraocular pressure, namely prostaglandin D2 and thromboxane A2 765698
Show all pathways known for 1.11.1.20Display the reaction diagram Show all sequences 1.11.1.20physiological function prostaglandin ethanolamide, i.e. prostamide, F2alpha is a COX-2-catalyzed metabolite of arachidonoyl ethanolamide (anandamide) that induces pharmacological actions in ocular tissues. Prostamide/PGF synthase catalyzes the reductions of prostamide H2 to prostamide F2alpha and PGH2 to PGF2alpha, chiefly in the central nervous system 707934
Show all pathways known for 1.11.1.20Display the reaction diagram Show all sequences 1.11.1.20physiological function the enzyme serves an important regulatory role in the eye by providing prostaglandin F2alpha and prostamide F2alpha to constrain the influence of those prostanoids that raise intraocular pressure 765698
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