EC Number   |
General Information |
Reference |
|---|
   1.10.5.1 | malfunction |
adult QR2 knock-out mice demonstrate enhanced learning abilities in various tasks, including Morris water maze, object recognition, and rotarod performance test, while other behaviors related to anxiety (elevated plus maze), depression (forced swim), and schizophrenia (prepulse inhibition) are not affected in QR2-deficient mice. QR2 inhibition protects hippocampal cells against menadione-induced toxicity and serum deprivation and can reverse cognitive deficits |
712829 |
| 1.10.5.1 | malfunction |
specific inhibitors of QR2, tested in vivo, show outstanding properties impairing memory loss |
725158 |
| 1.10.5.1 | more |
comparison of isoenzymes Qr1 and QR2, overview |
725071 |
| 1.10.5.1 | more |
QR2 does not share many features with QR1. Particularly, it does not seem to have a similar detoxifying function in cells. QR2 is overexpressed in neurodegenerative diseases |
725158 |
| 1.10.5.1 | physiological function |
cells overexpressing NQO2 show a significant increase in the ROS production due to the fast reduction of quinone into quinol that can re-oxidize to form superoxide radicals. NQO2 inhibition decreases the amount of superoxide cells overexpressing NQ2 by decreasing the amount of quinol formed, and it increases the toxicity of menadione in the cells co-expressing NQO2 with the conjugation enzyme UDPglucuronosyltransferase (UGT1A6, E.C. 2.4.1.17). For the cells coexpressing NQO2 and UGT1A6, the homeostasis dysregulation is lower in presence of menadione than for its counterpart expressing only NQO2 |
764767 |
| 1.10.5.1 | physiological function |
in NQ2 knockout cells, cell growth is slower. In a mouse model with xenografts formed by NQO2 knockout cells, the NQO2 knockout group exhibited significant smaller tumor volume and tumor weight than the control. Deletion of NQO2 suppresses cancer proliferation in vivo |
763861 |
| 1.10.5.1 | physiological function |
knockdown of NQO2 enhances the albumin secretion of primary hepatocytes |
763805 |
| 1.10.5.1 | physiological function |
NQO2 catalyzes the reduction of quinone-like metabolites derived from acetaminophen, clozapine, 4'-hydroxydiclofenac, mefenamic acid, amodiaquine, and carbamazepine. NQO2 may be a genetic risk factor for clozapine-induced agranulocytosis |
764465 |
| 1.10.5.1 | physiological function |
QR2 plays a role in cognitive behaviors |
712829 |
| 1.10.5.1 | physiological function |
quinone reductase 2 is an FAD-linked enzyme and the only known human target of two antimalarial drugs, primaquine and chloroquine, a functional role for NQO2 as a flavin redox switch |
725512 |
