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EC Number General Information Commentary Reference
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64drug target since 17beta-HSD3 plays a central role in testosterone production, it is a promising therapeutic target to reduce the circulating level of androgens and to suppress androgen-sensitive tumor proliferation 762479
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64drug target the enzyme is a potential therapeutic target for hormone-dependent prostate cancer 761168
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64evolution the enzyme belongs to the AKR1C subfamily, the members of which catalyze the reduction of ketosteroids and ketoprostaglandins 739797
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64malfunction AKR1C3 knockdown is accomplished in cultured adrenal cells (H295R) using small interfering RNA. Decreasing adrenal cell expression of AKR1C3 mRNA and protein inhibit testosterone production in the H295R adrenal cell line 712571
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64malfunction enzyme inhibition results in reduced cell proliferation 740162
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64malfunction mutations of HSD17B3 genes cause a 46,XY disorder of sexual development (46,XY DSD) as a result of low testosterone production 761760
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64metabolism enzyme 17beta-HSD3 acts in the last step of the biosynthesis of testosterone 740162
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64metabolism last step of testosterone biosynthesis 761168
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64metabolism the enzyme catalyzes the last step in the biosynthesis of the potent androgen testosterone (T), by stereoselectively reducing the C17 ketone of 4-androstene-3,17-dione (4-dione), with NADPH as cofactor -, 740916
Show all pathways known for 1.1.1.64Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.64physiological function AKR1C3 is an important human enzyme that participates in the reduction of steroids and prostaglandins, which leads to proliferative signalling. In addition, this enzyme also participates in the biotransformation of xenobiotics, such as drugs and procarcinogens. AKR1C3 is involved in the development of both hormone-dependent and hormone-independent cancers and confers cell resistance to anthracyclines. Role ofAKR1C3in hormone-dependent (e.g., breast, prostate and endometrium) and hormone-independent (e.g., lung, brain, and kidney) cancers 740912
Results 1 - 10 of 15 > >>