EC Number   |
General Information |
Reference |
|---|
    1.1.1.31 | evolution |
3-hydroxyisobutyrate dehydrogenase belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donors with NAD+ or NADP+ acceptors |
722472 |
| 1.1.1.31 | malfunction |
At4g20930 knockdown plants show increased root growth inhibition of the mutants if cultivated in the presence of Val or Ile but not in the presence of leucine |
762158 |
| 1.1.1.31 | metabolism |
the enzyme is involved in both, valine and isoleucine degradation in Arabidopsis thaliana |
762158 |
| 1.1.1.31 | more |
enzyme activity of HIBADH in spermatozoa from patients with asthenozoospermia is reduced compared to controls |
722472 |
| 1.1.1.31 | physiological function |
3-hydroxyisobutyrate dehydrogenase is a key enzyme for the metabolism of valine and some keto-bodies. It can catalyze reversible conversion of 3-hydroxyisobutyrate to methylmalonate semialdehyde |
-, 695710 |
| 1.1.1.31 | physiological function |
3-hydroxyisobutyrate dehydrogenase is one of the critical enzymes generating glucose by metabolizing amino acids in the gluconeogenesis pathway. It participates in valine, leucine, and isoleucine degradation and is a central metabolic enzyme in the valine catabolic pathway. The enzyme plays an important role in regulating sperm motility and may serve as a novel sperm-motility marker |
722472 |
| 1.1.1.31 | physiological function |
the enzyme plays a role in the assembly of motile polar flagellum and in biofilm biomass accumulation |
-, 760808 |
