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EC Number General Information Commentary Reference
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239evolution enzyme AKR1C34 is a member of the aldo–keto reductase (AKR) 1C subfamily in the AKR superfamily 740637
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239evolution the enzyme is a member of the aldo-keto reductase (AKR) superfamily that metabolizes endogenous substrates, such as carbohydrates, prostaglandins and steroids, and xenobiotics in a NAD(P)(H)-dependent manner 739864
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239evolution the enzyme is a member of the aldo–keto reductase (AKR) 1C subfamily in the AKR superfamily 739953
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239malfunction mutation of Tyr118 and Phe310 in AKR1C27 to the corresponding residues (Phe and Ile, respectively) in AKR1C28 produces an enzyme that is similar to AKR1C28 739953
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239more Homology structure modeling of AKR1C28 on the basis of sequence alignment and crystal structure analysis of the AKR1C5 ternary complex, PDB ID 1Q13, overview 739953
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239more structure analysis by homology modelling, overview 739953
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239more the structure of the AKR1C3-NADP+ complex is solved by molecular replacement, overview 725674
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239more Tyr118 and Phe310 play key roles in ligand binding. Homology structure modeling of AKR1C27 on the basis of sequence alignment and crystal structure analysis of the AKR1C5 ternary complex, PDB ID 1Q13, overview 739953
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239physiological function AKR1C3 catalyzes the conversion of the weak androgen precursors 4-androstene-3,17-dione and 5alpha-androstane-3,17-dione to the potent androgens testosterone and 5alpha-dihydrotestosterone (DHT), respectively, and is one of the most highly upregulated genes in castrate-resistant prostate cancer, CRPC 725674
Show all pathways known for 1.1.1.239Display the word mapDisplay the reaction diagram Show all sequences 1.1.1.239physiological function aldo-keto reductase 1C3 (AKR1C3), also known as type 5 17beta-hydroxysteroid dehydrogenase, is a downstream steroidogenic enzyme and converts androgen precursors to the potent androgen receptor ligands testosterone and 5alpha-dihydrotestosterone. AKR1C3 is involved in the development of castration resistant prostate cancer (CRPC) 740293
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