EC Number   |
General Information |
Reference |
|---|
   1.1.1.159 | evolution |
7alpha-HSDHs is a member of SDR superfamily and belongs to the classical subfamily with the cofactor binding site sequence motif TA/G/SxxxGIG and the active site sequence motif YxxxK (x = any amino acid residue) |
740787 |
| 1.1.1.159 | evolution |
7alpha-hydroxysteroid dehydrogenase is a member of the short-chain dehydrogenase/reductase superfamily |
741371 |
| 1.1.1.159 | evolution |
the enzyme is a member of the short-chain dehydrogenase/reductase (SDR) superfamily |
-, 740971 |
| 1.1.1.159 | malfunction |
a 7alpha -HSD knockout mutant shows decreased degradation of testosterone, estradiol and cholesterol compared to the wild-type |
-, 740971 |
| 1.1.1.159 | more |
molecular dynamics simulation of cofactor NADPH and taurochenodeoxycholic acid bound to the enzyme, overview. The C-terminal structure of CA 7alpha-HSDH does not directly surround the substrate-binding pocket but stretch outward. The Ser-Tyr-Lys triad is well conserved in other 7alpha-HSDHs but not in the CA 7alpha-HSDH |
740787 |
| 1.1.1.159 | more |
the C-terminus and residue Arg38 are essential for activity of the 7alpha-hydroxysteroid dehydrogenase from Clostridium absonum |
741371 |
| 1.1.1.159 | more |
the enzyme sequence contains a Tyr-X-X-X-Lys segment, residues 161-165, that is essential for catalytic activity of SDR proteins |
-, 740971 |
| 1.1.1.159 | physiological function |
the enzyme CA 7alpha-HSDH is responsible for reversibly catalysing the oxidation of C7alpha-oriented hydroxyl of the steroid nucleus in the bile acid metabolism |
740787 |
| 1.1.1.159 | physiological function |
the enzyme catalyzes the dehydrogenation of C7 hydroxyl group of the steroid skeleton of bile acids |
741371 |
