EC Number   |
General Information |
Reference |
|---|
   7.2.2.20 | drug target |
as the enzyme is critical for survival in metal-limited environments such as the human host, makes it attractive as potential antibiotic drug target |
-, 766956 |
| 7.2.2.20 | drug target |
high-affinity zinc uptake system is important for survival and virulence, making them attractive targets for the development of novel antibiotics |
-, 765952 |
| 7.2.2.20 | malfunction |
a deletion mutant of subunit znuA drastically reduces the ability of Salmonella enterica to multiply in media deprived of zinc, impairs its ability to grow in Caco-2 epithelial cells, and lead to decreased ability to multiply in phagocytes under zinc starving conditions |
-, 753794 |
| 7.2.2.20 | malfunction |
deletion of either ZnuABC1 or ZnuABC2 does not lead to growth defects. Simultaneous deletion of both transporters causes severe growth defects |
767057 |
| 7.2.2.20 | malfunction |
enzyme deletion mutants show lower resistance to oxidative stress under zinc deprivation compared to the wild type enzyme |
752494 |
| 7.2.2.20 | malfunction |
enzyme lack perturbs zinc homoeostasis |
-, 754025 |
| 7.2.2.20 | malfunction |
inactivation of the subunit gene znuA significantly decreases Escherichia coli O157:H7 ability to grow in zinc depleted media. Lack of subunit ZnuA affects the adhesion ability of the bacteria to cultured epithelial cells |
753099 |
| 7.2.2.20 | malfunction |
Salmonella strains producing a modified form of subunit ZnuA which lacks a characteristic histidine-rich domain exhibit a ZinT-dependent capability to import zinc either in vitro or in infected mice |
-, 754010 |
| 7.2.2.20 | malfunction |
the absence of enzyme-mediated zinc uptake affects virulence-associated phenotypes of Escherichia coli CFT073 under zinc-depleted conditions. The subunit znuB-deletion mutant is significantly deficient in the formation of biofilm under static conditions and also shows a substantially reduced migration front of swarm cells |
-, 753588 |
| 7.2.2.20 | malfunction |
the deletion of znuACB genes results in growth perturbation and a sharp decrease in the ability of biofilm formation and adhesion of bacteria in vitro |
-, 768091 |
