EC Number   |
General Information |
Reference |
|---|
  6.2.1.76 | malfunction |
aae13 null mutants grow poorly and accumulated malonic and succinic acids |
765555 |
| 6.2.1.76 | malfunction |
loss of ACSF3 perturbs mitochondrial metabolism. Impaired mitochondrial malonate metabolism affects cellular energy status and impairs de novo lipogenesis |
764430 |
| 6.2.1.76 | metabolism |
a major role for ACSF3 is to provide a metabolic pathway for the clearance of malonate by the generation of malonyl-CoA, which can then be decarboxylated to acetyl-CoA by malonyl-CoA decarboxylase. Additionally, ACSF3-derived malonyl-CoA can be used to malonylate lysine residues on proteins within the matrix of mitochondria, possibly adding another regulatory layer to post-translational control of mitochondrial metabolism |
763858 |
| 6.2.1.76 | metabolism |
overexpression of a malonyl-CoA synthetase leads to significant increase in both lipid and polyketide accumulation. AAE13 expression increases lipid accumulation. Overexpression of AAE13 leads to significant increases in resveratrol accumulation. Overexpression of AAE13 suppresses the TCA cycle in transgenic yeast |
764005 |
| 6.2.1.76 | metabolism |
the enzyme is not inducible |
-, 764093 |
| 6.2.1.76 | metabolism |
the enzyme plays a key role in malonate metabolism |
764096 |
| 6.2.1.76 | physiological function |
AAE13 is required to metabolize free malonate and prevent its accumulation to levels that are toxic to cell metabolism and plant growth |
765555 |
| 6.2.1.76 | physiological function |
ACSF3 is involved in the formation of the malonyl-ACP moieties required as substrates for the mitochondrial de novo fatty acid synthesis pathway |
765038 |
| 6.2.1.76 | physiological function |
essential role for the enzyme (ACSF3) in dictating the metabolic fate of mitochondrial malonate and malonyl-CoA in mammalian metabolism. ACSF3 is required for the metabolism and therefore detoxification of malonate, ACSF3-derived malonyl-CoA is specifically required for lysine malonylation of mitochondrial proteins |
764430 |
| 6.2.1.76 | physiological function |
whereas the cytosolic AAE13 protein is not essential, due to the presence of a redundant malonyl-CoA generating system provided by a cytosolic acetyl-CoA carboxylase, the mitochondrial AAE13 protein is essential for plant growth |
765574 |
