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EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 4.3.2.5more the the peptidyl-alpha-hydroxyglycine alpha-amidating lyase (PAL) is located on a domain of peptidylglycine alpha-amidating monooxygenase (PAM). The monooxygenase reaction is a slower step in peptide amidation, so that in peptidylglycine alpha-amidating monooxygenase (PAM) deficient mice, peptidyl-alpha-hydroxyglycine alpha-amidating lyase becomes the limiting factor of conversion of amidated peptides, overview. Peptidylglycine-alpha-hydroxylating monooxygenase, PHM, and peptidyl-alpha-hydroxyglycine alpha-amidating lyase, PAL, are stitched together in most vertebrates, kinetic studies with purified PHM and PAL revealed a higher affinity of PHM for its peptide substrate and a higher turnover number for PAL -, 730684
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