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EC Number
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Commentary
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4.3.1.B2
metabolism
key metabolic enzyme,which links amino acid and nucleottide biosynthesis. It uses the substrates glutamine and N'-[(5-phosphoribulosyl)formimino]-5-aminoimidazole-4-carboxamide-ribonucleotide to catalyze the closure of the imidazole ring within histidine biosynthesis and additionally provides 5-aminoimidazole-4-carboxamide ribotide for use in the de novo synthesis of purines
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728807
4.3.1.B2
metabolism
the enzyme catalyzes the fifth step in the histidine biosynthetic pathway located at the branch point to de novo purine biosynthesis
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727791
4.3.1.B2
metabolism
the enzyme links histidine and de novo purine biosynthesis
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,
748148
4.3.1.B2
physiological function
the enzyme represents a junction between histidine biosynthesis and de novo purine biosynthesis
728731
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