EC Number   |
General Information |
Reference |
|---|
   4.2.1.B28 | evolution |
tetrahymanol synthase (Ths) is found in a variety of bacterial genomes, including aerobic methanotrophs, nitrite-oxidizers, and sulfate-reducers, and in a subset of aquatic and terrestrial metagenomes. The potential to produce tetrahymanol is more widespread in the bacterial domain than previously thought. Ths is not encoded in any eukaryotic genomes, nor is it homologous to eukaryotic squalene-tetrahymanol cyclase (EC 4.2.1.123), which catalyzes the cyclization of squalene directly to tetrahymanol |
-, 749171 |
| 4.2.1.B28 | more |
hopanoids, tetrahymanol, and sterol structures observed in Methylomicrobium alcaliphilum strain 20Z, overview |
-, 749171 |
| 4.2.1.B28 | physiological function |
tetrahymanol, whose catalysis is synthesized by tetrahymanol synthase, is a polycyclic triterpenoid lipid. Enzyme tetrahymanol synthase (Ths) functions on hopenes rather than squalene, it first demethylates squalene to form C23-norsqualene, which is then converted to a demethyl derivative of tetrahymanol by squalene-hopene cyclase (Shc, EC 5.4.99.17). This pathway requires the addition of a methyl group at C-23 to form tetrahymanol. Enzyme Shc cyclizes squalene to diploptene, and Ths then expands the E ring to form tetrahymanol, overview |
-, 749171 |
