EC Number   |
General Information |
Reference |
|---|
  4.1.1.84 | physiological function |
chronic UVB exposure accelerates tumor development in DDT overexpressing mice, with a higher incidence of tumors observed in DDT overexpressing mice than in wild-type mice. In DDT overexpressing irradiated mouse keratinocytes, the p53, PUMA, and Bax expression is lower than that in wild-type |
771030 |
| 4.1.1.84 | physiological function |
DDT promotes proliferation of and prevents staurosporine-induced apoptosis in A-549 lung epithelial cells. DDT also stimulates growth of primary alveolar epithelial cells. DDT treatment results in significantly more and larger murine and human alveolar organoids compared to untreated controls. The anti-apoptotic effect of DDT and DDT-induced organoid growth are inhibited in the presence of an ACKR3-blocking nanobody. DDT complexes with ACKR3. DDT can activate the PI3K-Akt pathway which is enhanced in ACKR3-overexpressing cells |
770722 |
| 4.1.1.84 | physiological function |
DDT protein levels are significantly elevated within neurons and astrocytes following spinal cord injury. Recombinant DDT is efficient in inducing the production of inflammatory cytokines from astrocytes through interaction with CD74 receptor. Activation of mitogen-activated protein kinases and NF-kappaB is essential for the transduction of DDT signaling |
770136 |
| 4.1.1.84 | physiological function |
recombinant DDT is able to activate the COX2/PGE2 signal pathway of astrocytes through CD74 receptor, the intracellular activation of mitogen-activated protein kinases is involved in the regulation of DDT action. Inhibition of DDT promotes the recovery of motor function following spinal cord injury |
773616 |
| 4.1.1.84 | physiological function |
treatment with a DDT-specific antibody induces themigration of monocytes/macrophages and lymphocytes both in vitro and in vivo, without significant influence on the migration of neutrophils. Recombinant DDT exhibits chemotactic activity for lipopolysaccharide-stimulated M1-type monocytes/macrophages in vitro |
776244 |
