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Results 1 - 9 of 9
EC Number General Information Commentary Reference
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22physiological function Arabidopsis Nudix hydrolase, AtNUDX19, has NADPH hydrolytic activity in vitro and is a regulator of the NADPH status. Role of ANUDX19 in regulation of the salicylic acid response in a negative manner. ANUDX19 acts as an NADPH diphosphohydrolase to modulate cellular levels and redox states of pyridine nucleotides and fine-tunes photooxidative stress response through the regulation of photosynthesis, antioxidant system, /and possibly hormonal signaling. The redox states of NADP(H) are crucial for regulating both ROS production and scavenging in chloroplasts. AtNUDX19 regulates NADPH levels and activity of enzymes involved in the NADPH production in Arabidopsis thaliana leaves and roots. AtNUDX19 catalyzes the hydrolysis of NADPH, but not NADH, in vivo and has significant impacts on the cellular levels and redox states of pyridine nucleotides 758387
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22malfunction deletion of the NADH pyrophosphatase gene nudC results in increased susceptibility to isoniazid and ethionamide 720498
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22physiological function deletion of the UshA gene leads to faster cell growth and improves extracellular NAD stability by 3fold under conditions similar to whole-cell biocatalysis -, 733748
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22more insights on isoniazid killing mechanism by microfluidics and automated time-lapse microscopy single-cell analysis, overview -, 758393
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22physiological function mycobacterial NADH diphosphatase isoforms play an important role for the mechanism of isoniazid (INH) and ethionamide activation. INH has been one of the most effective and widely used antitubercular drugs, it is a pro-drug that is oxidatively activated in vivo by the katG-encoded mycobacterial catalase-peroxidase to generate covalently modified INH-NAD adduct. INH-NAD adduct inhibits InhA, an enoyl reductase that is a member of the type II dissociated fatty acid biosynthesis pathway. INH interferes with the biosynthesis of mycolic acids, the very long chain fatty acid components of the mycobacterial cell wall -, 758393
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22physiological function NADH pyrophosphatase NudC plays an important role in the inactivation of isoniazid and ethionamide 720498
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22malfunction nudx19 mutants accumulate salicylic acid and show high sensitivity to the hormone. Physiological role of AtNUDX19 using its loss-of-function mutants. NADPH levels are increased in nudx19 mutants under both normal and high light conditions, while NADP+ and NAD+ levels are decreased. Despite the high redox states of NADP(H), nudx19 mutants exhibit high tolerance to moderate light- or methylviologen-induced photooxidative stresses. The tolerance of nudx19 mutants to photooxidative stress is due to an enhancement in photosynthesis, increase in antioxidant capacity, and/or modulation of the expression of defense genes through changes in the levels and redox states of NAD(P), phenotypes, overview. AtNUDX19 acts as a negative regulator of SA synthesis. In contrast, KO- and KD-nudx19 plants are slightly insensitive to jasmonic acid methyl (MeJA) and abscisic acid (ABA). This might be explained by the fact that SA acts as an antagonist of these hormones. The expression of AtNUDX19 is also responsive to treatments with these hormones 758387
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22evolution structure and phylogenetic tree of AtNUDX19-type (SQPWP) enzymes, structure of subgroup I (including AtNUDX19) and II 758387
Show all pathways known for 3.6.1.22Display the word mapDisplay the reaction diagram Show all sequences 3.6.1.22malfunction the msm1946-NADH pyrophosphatase mutant shows increased killing rate during exposure to isozianide and ethionamide (INH and ETH) as compared to wild-type. The msm1946::Tn transposon mutant grows indistinguishably from wild-type bacteria in standard 7H9 liquid medium. The ability of the mutant cells to form colonies on standard LB solid medium is also indistinguishable from wild-type cells. The impact of msm1946 disruption on drug-mediated killing is found to be specific to INH and ETH. Elevated levels of NADH in the msm1946::Tn mutant can contribute to enhanced formation of the INH-NAD adduct -, 758393
Results 1 - 9 of 9