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EC Number
General Information
Commentary
Reference
physiological function
APOBEC3G is a single-stranded DNA cytidine deaminase capable of restricting retroviral replication
physiological function
APOBEC3G protein inhibits HCV replication through direct binding at non-structural protein NS3 at its C-terminus, which is responsible for NS3's helicase and NTPase activities
physiological function
the enzyme causes C to T mutations in the cDNA copy of the HIV-1 genome
physiological function
the enzyme causes mutational diversity by initiating mutations on regions of single-stranded DNA. The enzyme enters the cytoplasm of the targeted T cell and catalyzes C deaminations on reverse transcribed cDNA causing HIV-1 retroviral inactivation. Enzyme-initiated mutations boost human fitness and restricts HIV-1 replication in the absence of the viral infectivity factor. The enzyme is involved in hepatic metastasis of colorectal cancer
physiological function
the enzyme exhibits anti-human immunodeficiency virus-1 (HIV-1) activity by deaminating cytidines of the minus strand of HIV-1. Virus infectivity factor of HIV-1 counteracts the anti-HIV-1 activity of the enzyme
physiological function
the enzyme inhibits HIV replication and inhibits retroviral infection by deaminating first strand cDNA, generating viral DNA mutations and potential viral elimination
physiological function
the enzyme is a single-stranded DNA cytosine deaminase that functions in innate immunity against retroviruses and retrotransposons. The enzyme can potently restrict virus infectivity factor-deficient HIV-1 replication by catalyzing excessive levels of G->A hypermutation. Sublethal levels of enzyme-catalyzed mutation may contribute to the high level of HIV-1 fitness and its incurable prognosis
physiological function
the enzyme is an endogenous inhibitor of human immunodeficiency virus type 1 (HIV-1) replication, able to induce G to A hypermutation in newly synthesized viral DNA
physiological function
the enzyme is an important component of the cellular innate immune response to retroviral infection. The enzyme APOBEC3G can extinguish HIV-1 infectivity by its incorporation into virus particles and subsequent cytosine deaminase activity that attacks the nascent viral cDNA during reverse transcription, causing lethal mutagenesis. The enzyme can also induce sublethal mutagenesis, which maintains virus infectivity and contribute to HIV-1 variation
physiological function
the enzyme is capable of blocking retrovirus replication by editing viral cDNA and impairing reverse transcription
Results 1 - 10 of 14 > >>