Refine search

Search General Information

show results
Don't show organism specific information (fast!)
Search organism in taxonomic tree (slow, choose "exact" as search mode, e.g. "mammalia" for rat,human,monkey,...)
(Not possible to combine with the first option)
Refine your search

Search term:

Results 1 - 2 of 2
EC Number
General Information
Commentary
Reference
malfunction
defective prelamin A processing induces accelerated features of age-related bone loss including lower osteoblast and osteocyte numbers and higher levels of marrow adipogenesis
physiological function
Zmpste24-null progeroid mice exhibit nuclear lamina defects and accumulate unprocessed prelamin A. Defective prelamin A processing induces accelerated features of age-related bone loss including lower osteoblast and osteocyte numbers and higher levels of marrow adipogenesis. There is a significant loss in trabecular and cortical bone between the Zmpste24 -/- mice compared with the wild-type controls. At 3 months of age, Zmpste24 -/- mice show a significant decrease in bone volume/tissue volume, trabecular thickness, and trabecular number compared with their wild-type littermates
Results 1 - 2 of 2