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Results 1 - 5 of 5
EC Number
General Information
Commentary
Reference
evolution
the enzyme belongs to the SENP/ULP protease family
malfunction
cells lacking SENP6 show defects in spindle assembly and metaphase chromosome congression. A subset of proteins becomes undetectable on inner kinetochores after SENP6 depletion, particularly the CENP-H/I/K complex
malfunction
depletion of SENP6 results in accumulation of endogenous SUMO-2/3 and SUMO-1 conjugates, and in accumulation of SUMO and promyelocytic leukemia protein in an increased number of promyelocytic leukemia nuclear bodies. Although SENP6 depletion drastically increases the size of promyelocytic leukemia nuclear bodies, the organizational structure of the body is not affected
more
active site loop1 insertion is the determinant for the SUMO2/3 activity and specificity of SENP6, role of the SENP6/7-loop1 insertion in chain dismantling
physiological function
SENP6 is essential for inner kinetochore assembly. Balanced activities of SENP6 and RNF4 control vertebrate kinetochore assembly through SUMO-targeted destabilization of inner plate components
Results 1 - 5 of 5