EC Number   |
General Information |
Reference |
|---|
   3.4.22.69 | physiological function |
3CLpro is required for viral replication |
707802 |
| 3.4.22.69 | physiological function |
3CLpro is vital for SARS-coronavirus replication |
710675 |
| 3.4.22.69 | more |
autoprocessing mechanism of the enzyme |
731790 |
| 3.4.22.69 | drug target |
based on the near-identical substrate specificities and high sequence identities (between SARS-CoV-2 and SARS-CoV (86%)), some of the previous progress of specific inhibitors development for the SARS-CoV enzyme can be conferred on its SARS-CoV-2 counterpart: the antivirals ledipasvir or velpatasvir, the drugs Epclusa (velpatasvir/sofosbuvir) and Harvoni (ledipasvir/sofosbuvir) can be effective |
753527 |
| 3.4.22.69 | drug target |
combination of thioacetal functional group with decahydroisoquinolin or related fused-ring scaffold would be an approach to design inhibitors for SARS 3CL protease |
752974 |
| 3.4.22.69 | drug target |
due to its essential role in processing the polyproteins that are translated from the viral RNA, the enzyme is an attractive drug target among coronaviruses |
755546 |
| 3.4.22.69 | drug target |
due to its essential role in processing the polyproteins that are translated from the viral RNA, the enzyme is an attractive drug target among coronaviruses. The pharmacokinetic characterization of the optimized inhibitor reveals a pronounced lung tropism and suitability for administration by the inhalative route |
755546 |
| 3.4.22.69 | physiological function |
during the formation of the coronaviral replication/transcription complex, essential steps include processing of the conserved polyprotein nsp7-10 region by the main protease Mpro and subsequent complex formation of the released nsps |
752729 |
| 3.4.22.69 | metabolism |
enzyme undergoes N-terminal and C-terminal autoprocessing using subsite cooperativity. In a dimer of the 3CLpro proform, containing a 10-residue C-terminal prosequence, and the C145A mutation of the catalytic cysteine residue, one of these prosequences is bound, as a substrate, to the active site of a subunit from an adjacent asymmetric unit. Residue Phe at the P3' position is required when the P2 residue is Phe |
755253 |
| 3.4.22.69 | physiological function |
essential enzyme for the completion of the life cycle of Middle East Respiratory Syndrome Coronavirus |
753344 |
