EC Number |
General Information |
Reference |
---|
3.4.21.B26 | evolution |
the enzyme belongs to the Ca2+-dependent proprotein convertase family of enzymes |
731899 |
3.4.21.B26 | evolution |
the enzyme is a serine protease of the proprotein convertase family |
732515 |
3.4.21.B26 | malfunction |
complete knockout of PC5/6 is lethal between E4.5-7.5 |
718009 |
3.4.21.B26 | malfunction |
enzyme-knockout endometrial epithelial cells show reduced capacity to attach to trophoblast spheroids and bind to fibronectin compared with control. Knockdown of the enzyme decreases cell surface presentation of functional integrins-alpha1, alpha2, alpha5, alphaV and alphaVbeta5 |
731899 |
3.4.21.B26 | malfunction |
gene inactivation of PC5/6 leads to lethality at birth, the lack of PC5/6 in enterocytes results in a significantly higher tumor number in the duodenum, the absence of PC5/6 is also associated with a premature mortality of ApcMin/+ mice that harbor a heterozygote multiple intestinal neoplasia mutation in the adenomatous polyposis coli gene |
709911 |
3.4.21.B26 | malfunction |
PC5/6-knockout mouse embryos show developmental abnormalities, and reduced overall mineralization |
753112 |
3.4.21.B26 | malfunction |
PC6 knockdown reduces removal of alpha-dystroglycan N-terminus from endometrial epithelial cell surface and blastocyst adhesion |
753529 |
3.4.21.B26 | malfunction |
specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases BMP-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers |
752449 |
3.4.21.B26 | malfunction |
specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases bone morphogenetic protein-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers. Enzyme inhibition by decanoyl-Arg-Val-Lys-Arg-chloromethylketone and bone morphogenetic protein receptor inhibition by LDN-193189 suppress squamous differentiation, promote mucociliary differentiation, and down-regulate the BMP-2/Smad1/5/8/p38 signaling pathways |
731111 |
3.4.21.B26 | metabolism |
the enzyme in the human endometrium is tightly regulated during receptivity for embryo implantation |
731899 |