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Results 1 - 10 of 19 > >>
EC Number General Information Commentary Reference
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26evolution the enzyme belongs to the Ca2+-dependent proprotein convertase family of enzymes 731899
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26evolution the enzyme is a serine protease of the proprotein convertase family 732515
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26malfunction complete knockout of PC5/6 is lethal between E4.5-7.5 718009
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26malfunction enzyme-knockout endometrial epithelial cells show reduced capacity to attach to trophoblast spheroids and bind to fibronectin compared with control. Knockdown of the enzyme decreases cell surface presentation of functional integrins-alpha1, alpha2, alpha5, alphaV and alphaVbeta5 731899
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26malfunction gene inactivation of PC5/6 leads to lethality at birth, the lack of PC5/6 in enterocytes results in a significantly higher tumor number in the duodenum, the absence of PC5/6 is also associated with a premature mortality of ApcMin/+ mice that harbor a heterozygote multiple intestinal neoplasia mutation in the adenomatous polyposis coli gene 709911
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26malfunction PC5/6-knockout mouse embryos show developmental abnormalities, and reduced overall mineralization 753112
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26malfunction PC6 knockdown reduces removal of alpha-dystroglycan N-terminus from endometrial epithelial cell surface and blastocyst adhesion 753529
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26malfunction specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases BMP-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers 752449
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26malfunction specific lentiviral short hairpin RNA-mediated PC5/6A knockdown decreases bone morphogenetic protein-2 expression and maturation, decreases expression of squamous cell markers, and increases expression of ciliated cell markers. Enzyme inhibition by decanoyl-Arg-Val-Lys-Arg-chloromethylketone and bone morphogenetic protein receptor inhibition by LDN-193189 suppress squamous differentiation, promote mucociliary differentiation, and down-regulate the BMP-2/Smad1/5/8/p38 signaling pathways 731111
Display the word mapDisplay the reaction diagram Show all sequences 3.4.21.B26metabolism the enzyme in the human endometrium is tightly regulated during receptivity for embryo implantation 731899
Results 1 - 10 of 19 > >>